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AICAR and BAC Water Mix

AICAR Reconstitution Calculator

Reviewed by · Pharmacist and Scientific Reviewer

Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.

What amount do you need?

Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.

Work the dose out from body weight

Syringe size:
Possible vial strengths:
Best Match Good Match Usable Harder to Measure

Example AICAR Titration Schedule

ContextDoseNote
Mouse endurance500 mg/kg daily ×4 wkNarkar 2008 (Cell)
Human history5 CABG surgery RCTsEndpoints not met; discontinued
Listed examples1 mg/kg; 0.7 g/kgNot traceable to any study

The famous mouse dose is exact (Narkar 2008: +44% running distance). The '1 mg/kg/day ×13 weeks' and '0.7 g/kg optimal' rows do not exist in any publication. Critical context: AICAR has been WADA-banned since 2009, is detectable via erythrocyte ribotide testing, and a 2012 police operation arrested a cycling-team doctor for its distribution. No therapeutic approval exists anywhere.

Possible vial strengths:

What Is It?

AICAR

AMPK activator research compound.

Bacteriostatic Water

Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.

How To Mix AICAR

1
Clean

Use alcohol swabs to clean the tops of both vials.

2
Draw BAC Water

Draw the selected amount of bacteriostatic water.

3
Inject Slowly

Add the liquid slowly down the side of the vial.

4
Swirl Gently

Do not shake. Swirl gently until dissolved.

5
Store Properly

Store as directed and protect from heat and light.

Best Practices & Common Mistakes

Best Practices

  • Use sterile technique.
  • Protect from light and heat.
  • Store refrigerated when appropriate.
  • Use clean syringe-unit math before measuring.

Common Mistakes

  • Confusing milligrams with milliliters.
  • Choosing an option with awkward decimal units.
  • Using too little liquid for very small measurements.
  • Shaking the vial aggressively.

AICAR Storage & Handling

Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.

Frequently Asked Questions

AICAR, also called acadesine or AICA-riboside, is a research compound used to study AMPK signaling and cellular energy metabolism. It is often marketed beside peptides, but it is not a peptide; it is a nucleoside-related compound that can be converted inside cells into ZMP.
No. AICAR is a research compound, while A1C or HbA1c is a blood test used to estimate average blood sugar over about three months. If someone searches “normal AIC,” they usually mean A1C, not AICAR.
AICAR is commonly called a “peptide” online because it appears on peptide-research websites, but chemically that label is wrong. For calculator users, the important point is that AICAR is handled as a research compound with concentration math, not as a normal amino-acid peptide chain.
AICAR calculator math starts with the vial amount and final liquid volume. For example, a 50 mg AICAR vial brought to 8 mL final volume gives 6.25 mg/mL; a 2 mg research amount would equal 0.32 mL, or 32 units on a U-100 syringe.
The main safety issue is that AICAR affects energy-signaling biology, and not all effects are simply “AMPK activation.” It also has anti-doping relevance: AICAR is listed as a prohibited metabolic modulator in sport, so endurance and “exercise mimetic” claims should be treated carefully.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.

More Research & Investigational calculators

PNC-27 YK-11

References

  1. Narkar VA, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008.

About the author

· Pharmacist and Scientific Reviewer

Maria Hrabina is a pharmacist and scientific reviewer with a strong interest in peptide science, pharmacology, and emerging therapeutic compounds.

Her work focuses on understanding how peptide-based compounds interact with biological signaling pathways and how they are being investigated across areas such as metabolic health, dermatology, recovery, regenerative research, and pharmaceutical development.

Maria follows research on a broad range of peptides, from compounds used in approved medicines to experimental molecules still being evaluated in laboratory, preclinical, and clinical studies.

Her approach combines scientific curiosity with critical evaluation of evidence. She believes promising mechanisms and early research deserve attention, but should not be presented as established clinical benefits until they are supported by adequate human data.

Her areas of focus include scientific literature review, mechanisms of action, pharmacology, pharmacokinetics, safety, pharmaceutical formulation, and the overall quality of evidence behind peptide-based compounds.

She is particularly interested in the process of translating an experimental molecule into a reliable pharmaceutical product — including compound characterization, purity, stability, formulation, dose selection, safety assessment, and controlled clinical trials.

Maria believes peptide science has significant long-term potential, but that its progress depends on rigorous research, high manufacturing standards, transparent safety data, and responsible scientific communication.

Through her writing, she aims to help readers understand both sides of peptide research: what makes these compounds scientifically promising and what questions remain before their potential can be considered clinically established.

Areas of interest: Peptide Science · Therapeutic Peptides · Peptide Pharmacology · Metabolic Peptides · Cosmetic Peptides · Drug Development · Pharmacokinetics · Drug Safety · Pharmaceutical Formulation · Emerging Therapies · Evidence-Based Medicine

Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.
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