Growth-hormone secretagogues work indirectly: instead of supplying growth hormone, they prompt the pituitary to release its own, which makes timing and dose frequency matter more than dose size. Most of this group saturates the receptor at around 100 mcg per pulse, and continuous daily use measurably blunts the response — which is why the documented protocols build in rest days. Only sermorelin was ever FDA-approved, and that approval lapsed. The calculators here cover reconstitution and syringe units; the titration tables note where a circulating protocol has no trial behind it. Worth knowing before you compare pages: these compounds differ sharply in selectivity. Some raise cortisol and prolactin alongside growth hormone once the dose passes saturation, one is the strongest appetite trigger in its class, and one desensitises fastest of all — which is why their cycle lengths are not interchangeable.
