Tesamorelin Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Work the dose out from body weight
Syringe size:
Possible vial strengths:
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Example Tesamorelin Titration Schedule
| Item | FDA label | Off-label community |
|---|---|---|
| Dose | 2 mg once daily | 1–2 mg/day |
| Frequency | Every day, no breaks | 5-on/2-off or daily |
| Cycle | Continuous | 8–12 wks + breaks |
FDA label (Egrifta): 2 mg once daily, continuous — no cycling. The effect is visceral-fat-specific and reverses after stopping. 'Multiple injections per day' is incorrect: once-daily dosing is the label. Half-life of the compound is short but the downstream GH/IGF-1 effect sustains daily dosing.
Possible vial strengths:
What Is It?
Tesamorelin
Stabilised GHRH analogue.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Tesamorelin
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Tesamorelin Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
Tesamorelin is a stabilized analog of GHRH (growth hormone–releasing hormone) — a 44-amino-acid peptide with a chemical modification that makes it last longer in the body. It binds the pituitary's GHRH receptor to trigger natural pulses of your own growth hormone, which then raises IGF-1; it is not a steroid and not growth hormone itself. It's notable as the only FDA-approved GHRH analog, sold as Egrifta / Egrifta SV.
The FDA-approved regimen is a once-daily subcutaneous injection into the abdomen; the long-standing labeled dose is 2 mg per day (the newer Egrifta SV delivers an equivalent 1.4 mg in 0.35 mL). No — you do not have to be asleep for it to work; the peptide triggers a GH pulse whenever you inject it. Some clinicians suggest bedtime dosing to line up with your natural overnight GH surge, but consistency matters more than the exact hour, and these specifics should come from a prescriber.
Add bacteriostatic water to the dry vial slowly and swirl gently — don't shake. For example, a 10 mg vial + 2 mL of water gives 5 mg/mL, so a 2 mg dose is 0.4 mL, which is 40 units on a U-100 insulin syringe. Note that tesamorelin is dosed in milligrams, not the micrograms used for GHRPs — so the volumes are larger and easier to draw. Use the calculator above for your exact vial size and target dose.
Tesamorelin's defining, FDA-approved effect is reducing visceral fat — the deep fat around the organs — specifically in HIV-associated lipodystrophy; it also lowers fat in the liver. Importantly, it is weight-neutral and not approved as a general weight-loss drug: it reshapes where fat sits more than it drops the number on the scale, and it doesn't target the subcutaneous fat just under the skin. That's also why its mechanism differs from GLP-1-class drugs like retatrutide — tesamorelin works by amplifying your own growth hormone rather than acting on appetite, and any combination is a clinical decision, not a calculator one.
Tesamorelin isn't known to cause cancer, but because it raises IGF-1 its FDA label lists active cancer (any type) as a contraindication, along with pregnancy and allergy to tesamorelin or mannitol — and its long-term cardiovascular safety has not been established. Commonly reported effects are joint aches, injection-site reactions, swelling in the limbs, and muscle pain. On storage, the approved Egrifta SV is kept at room temperature before mixing and used immediately once reconstituted, whereas research-grade lyophilized tesamorelin is usually refrigerated, kept out of light, and used within weeks after reconstitution — always follow your specific product's instructions. It is a prescription drug for its approved use and is banned by WADA in sport.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.