Ipamorelin Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Work the dose out from body weight
Syringe size:
Possible vial strengths:
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Example Ipamorelin Titration Schedule
| Item | Details |
|---|---|
| Dose | 100–300 mcg per injection |
| Frequency | 2–3× per day (1–7×/week understates) |
| Cycle | 8–12 weeks on / 4–8 off |
| Selectivity | No appetite/cortisol/prolactin effect |
The most selective GHRP (Raun 1998). Its Phase 2 trial in postoperative ileus failed the primary endpoint (p=0.15) and FDA's advisory committee voted 12-0 against compounding eligibility in October 2024. Frequency should read per-day, not per-week.
Possible vial strengths:
What Is It?
Ipamorelin
Selective ghrelin receptor agonist, mild GH pulse.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Ipamorelin
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Ipamorelin Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
Ipamorelin is a synthetic pentapeptide that works as a selective growth hormone secretagogue, binding the ghrelin receptor (GHS-R1a) in the pituitary to trigger short, natural-style pulses of growth hormone. It was originally developed by Novo Nordisk and is one of the most receptor-selective GHRPs, which is why it circulates as a research peptide rather than an approved medicine. It contains no growth hormone itself — it prompts your own pituitary to release more.
In research and clinical write-ups, ipamorelin is discussed in micrograms — commonly around 100–300 mcg per dose, subcutaneously, once or up to a few times a day. Because its half-life is only about 2 hours, doses are usually timed to an empty stomach and often before bed, when natural GH release peaks. These figures are not an approved schedule; the right amount, frequency, and whether it's appropriate at all are clinical decisions.
Add bacteriostatic water to the dry vial and let it dissolve without shaking. For example, a 5 mg vial + 2 mL of water gives 2.5 mg/mL (2,500 mcg/mL); a 250 mcg dose is then 0.1 mL, which is 10 units on a U-100 insulin syringe. Adjust the math to your vial's actual strength — the calculator above handles any vial size and target dose. Working in micrograms matters here, since ipamorelin doses are far smaller than the milligram doses used for GLP-1 peptides.
Ipamorelin's defining trait is selectivity: unlike older secretagogues such as GHRP-6, it raises growth hormone with little effect on cortisol, prolactin, or strong hunger signaling, so appetite spikes tend to be mild or absent. It does not directly raise testosterone — it acts on the GH/IGF-1 axis, not the reproductive hormone axis. This "clean" profile is exactly why it's the ghrelin-receptor half so often paired with a separate GHRH-type peptide that works through a different receptor; how any such pairing is dosed is a clinical decision, not something to merge on a calculator.
Despite ipamorelin's online reputation as the "safest" or "cleanest" peptide, that reputation rests mostly on short Phase II trials and anecdote — it has never been approved by the FDA or any major regulator and has limited long-term human safety data. Reported effects include injection-site reactions, headache, and water retention, and any sustained rise in GH/IGF-1 can affect blood sugar and insulin sensitivity, so it is not risk-free. Store lyophilized vials refrigerated and out of light; once reconstituted, keep them cold and use within a few weeks. Selectivity reduces certain side effects — it does not make an unapproved compound proven-safe.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.