Kisspeptin-10 Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Work the dose out from body weight
Syringe size:
Possible vial strengths:
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Example Kisspeptin-10 Titration Schedule
| Item | Details |
|---|---|
| Dose | 100–200 mcg per injection |
| Frequency | 2–3× per week |
| Critical rule | Never twice-daily beyond 2 weeks |
| Female timing | Follicular phase, stop after trigger |
The 2–3×/week rhythm is the one human protocol shown to sustain LH/FSH elevation (twice-daily dosing caused complete tachyphylaxis by day 14 in the controlled trial). Trial doses are nmol/kg-based; microgram conversions are unvalidated.
Possible vial strengths:
What Is It?
Kisspeptin-10
Kisspeptin fragment studied in reproductive signaling.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Kisspeptin-10
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Kisspeptin-10 Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
Kisspeptin-10 is a 10-amino-acid neuropeptide (the active C-terminal fragment of kisspeptin-54, encoded by the KISS1 gene) that sits at the very top of the reproductive hormone cascade. It binds the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus — it's the switch that tells those neurons to fire, initiating the whole chain that drives puberty, fertility, and sexual function. It is an investigational research peptide, not an approved drug.
It can raise testosterone, but indirectly and briefly: kisspeptin-10 switches on hypothalamic GnRH neurons, which release GnRH in its natural pulsatile pattern, prompting the pituitary to put out LH and FSH, which then drive the gonads. Because it's the most potent known trigger of GnRH neurons, even small amounts spark an LH surge. But its plasma half-life is only about 4 minutes, so its effect is short-lived and continuous high-dose exposure can blunt the receptor rather than help.
The three act at three different levels of the same chain. Kisspeptin-10 is highest up — it stimulates the hypothalamus to release its own GnRH; gonadorelin is one step down — it is GnRH, acting directly on the pituitary; and hCG is lowest — it mimics LH at the gonads, skipping the brain entirely. So kisspeptin is the most "upstream" and physiological trigger, while hCG is the most direct. They are not the same and aren't interchangeable.
Its most distinctive research area is sexual function: Imperial College studies found kisspeptin increased activity in brain regions tied to sexual arousal and improved subjective "happiness about sex," including in people with low desire — a brain-and-hormone effect that sets it apart from pure axis drugs. It's also studied as an IVF ovulation trigger (potentially with less risk of ovarian hyperstimulation), and in hypothalamic amenorrhea and menopausal hot flashes. All of this is early-stage (Phase 1/2) human research, not established treatment.
Reconstitute the lyophilized powder with bacteriostatic water: for a 5 mg vial, adding 4 mL gives 1.25 mg/mL, so a 250 mcg amount draws to 0.2 mL (20 units on a U-100 syringe); adjust the water volume to suit your dosing. It is not FDA-approved — only investigational and sold as a research compound — with limited human safety data and no established long-term profile, so fertility, testosterone, or libido concerns belong with a clinician. Storage: keep the dry powder cold and dark, and refrigerate reconstituted solution, using it within a few weeks.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.
References
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.