Triptorelin Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Work the dose out from body weight
Syringe size:
Possible vial strengths:
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Example Triptorelin Titration Schedule
| Use | Dose | Frequency |
|---|---|---|
| PCT / pulse | 100 mcg | Single dose, once |
| Prostate cancer | 3.75 mg | IM depot every 4 weeks |
| (alternatives) | 11.25 / 22.5 mg | every 12 / 24 weeks |
Continuous daily GnRH-agonist exposure suppresses the reproductive axis — that is the prostate-cancer mechanism (castration levels within weeks). The listed 12-week daily schedule produces the opposite of the intended recovery. Correct pulse use: a single 100 mcg injection, optionally followed by a SERM for 4–6 weeks.
Possible vial strengths:
What Is It?
Triptorelin
GnRH agonist reference peptide.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Triptorelin
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Triptorelin Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
Triptorelin is an FDA-approved prescription medication — a synthetic decapeptide that acts as a GnRH (gonadotropin-releasing hormone) agonist, about 100 times stronger than the natural hormone. In the US it's sold as Trelstar and Triptodur; in Europe as Decapeptyl and Diphereline. It's used for advanced prostate cancer, endometriosis, uterine fibroids, central precocious puberty, and as a trigger in assisted reproduction (IVF).
Triptorelin has a paradoxical, two-phase effect on the hormone axis. For the first 1–2 weeks it stimulates the pituitary and causes a "flare" — a surge in LH, FSH, and sex hormones (testosterone or estrogen). With continuous or depot exposure, the receptors downregulate and shut down, producing deep, sustained suppression of those hormones — essentially a reversible medical castration used to starve hormone-driven conditions.
Triptorelin, leuprolide (Lupron/Eligard), and goserelin (Zoladex) are all GnRH agonists with broadly comparable testosterone-suppressing effect — triptorelin is the most-used one in Europe, and they differ mainly in depot schedules and branding. hCG is the opposite: it directly stimulates the testes to make testosterone, so it raises hormones where triptorelin ultimately lowers them. They are not interchangeable, and the right choice is a clinical decision.
The approved depot products aren't a home reconstitution: they come as a microsphere vial plus a supplied diluent (sterile water via a MIXJECT adapter) and are mixed and injected intramuscularly by a clinician right before use, in fixed strengths (3.75 mg monthly, 11.25 mg 3-month, 22.5 mg 6-month). If you're reconstituting a research-grade triptorelin acetate powder instead, the math is standard — a 2 mg vial + 2 mL bacteriostatic water = 1 mg/mL, so 200 mcg = 0.2 mL (20 units on a U-100 syringe) — but that powder is not the same as the approved drug.
Triptorelin is a real, approved drug with serious effects — bone-density loss with long use, an initial tumor "flare" in prostate cancer, QT-interval and metabolic warnings — so it belongs under a doctor's supervision, not self-use. Despite its online reputation as a one-shot "post-cycle therapy" reset, it's a medical-castration agent: the wrong dose or repeat exposure drives sustained hormone suppression, the opposite of a restart, and it's WADA-banned for tested athletes. Storage: the approved depot is stored per its label (room temperature), while any lyophilized research powder is kept cold and dark and used soon after mixing.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.