Orforglipron Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Work the dose out from body weight
Syringe size:
Possible vial strengths:
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Example Orforglipron Titration Schedule
| Step | Dose Strength | Duration |
|---|---|---|
| 1 — Start | 0.8 mg once daily | At least 4 weeks |
| 2 — Titration | 2.5 mg once daily | At least 4 weeks |
| 3 — Titration | 5.5 mg once daily | At least 4 weeks |
| 4 — Titration | 9 mg once daily | As tolerated |
| 5 — Titration | 14.5 mg once daily | As tolerated |
| 6 — Maximum | 17.2 mg once daily | Maintenance |
FDA-approved (Foundayo, April 2026), the first oral non-peptide GLP-1. Steps 4–6 are optional — escalate by response and tolerability. Missed 7+ consecutive days: restart escalation at a lower dose. Do not combine with other GLP-1 drugs.
Possible vial strengths:
What Is It?
Orforglipron
Oral non-peptide GLP-1 receptor agonist.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Orforglipron
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Orforglipron Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
It's a once-daily oral GLP-1 receptor agonist from Eli Lilly, now sold under the brand name Foundayo. Unlike injectable GLP-1s, it's a small-molecule pill (not a peptide), so it isn't reconstituted, mixed, or injected — you swallow a tablet. It's also the first GLP-1 pill that can be taken any time of day without food or water restrictions.
Yes. The FDA approved it on April 1, 2026 as Foundayo, for adults with obesity or overweight with a weight-related condition, used alongside diet and exercise. That makes it one of the first oral GLP-1 options for weight management, after oral semaglutide (the Wegovy pill) was approved in December 2025.
Foundayo is a once-daily tablet taken at the same time each day, with or without food. The approved dose ladder steps up gradually — 0.8, 2.5, 5.5, 9, 14.5, up to a 17.2 mg maintenance dose — to ease stomach side effects. Because it's a fixed-strength pill, there's no measuring or mixing involved; the exact schedule is set by a prescriber.
No. Tirzepatide (Mounjaro/Zepbound) is an injectable peptide that acts on two receptors (GLP-1 and GIP). Orforglipron is an oral, non-peptide pill that acts on GLP-1 only. They're different molecules in different formats — orforglipron isn't an oral version of tirzepatide, even though both come from Eli Lilly.
Yes — orforglipron is one of the first. Most GLP-1 drugs are peptides that stomach acid breaks down, so they're injected; orforglipron is a small molecule that survives digestion, which is why it works as a daily tablet. Oral semaglutide (the Wegovy pill) is another oral option. A pill format means no needles, vials, or reconstitution at all.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.