Cortagen Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Work the dose out from body weight
Syringe size:
Possible vial strengths:
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Example Cortagen Titration Schedule
| Item | Details |
|---|---|
| Standard dose | 0.7–2.1 mg/day (raw rodent transposition); community 200 mcg ×10 days |
| Courses | 10–20 days, 2–3× per year |
| Originator dose | 10–1000× lower (Russian tradition) |
Mouse heart microarray: 110 genes altered, chromatin decondensation. 'Practically no side effects' is an originator-only claim across one research lineage. The '1–5 mg per dose' figure is a recurring placeholder that never matched a validated protocol for any bioregulator; sources disagree up to 1000× on real doses.
Possible vial strengths:
What Is It?
Cortagen
Cortical peptide bioregulator.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Cortagen
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Cortagen Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
Cortagen is a Khavinson "bioregulator" — a synthetic tetrapeptide (Ala-Glu-Asp-Pro, AEDP) designed to target the brain's cerebral cortex and nervous tissue at the gene level. It was created by analyzing the amino acids in Cortexin, a natural cattle-brain-cortex extract used in Russian neurology, and distilling that down to one defined short peptide. It's sold as an oral/sublingual form and as a research-grade injectable powder.
Cortagen and Cortexin share a purpose but not a form: Cortexin is the original whole cerebral-cortex extract (a mix of many peptides), while Cortagen is the single synthetic tetrapeptide distilled from it. Pinealon (Glu-Asp-Arg) also comes from Cortexin analysis but is a different sequence aimed more broadly at brain neurons. And watch the letters — Cortagen (AEDP) is easily confused with Epitalon (AEDG), but Epitalon is the pineal, anti-aging peptide, not a cortex one.
In cell and animal studies, Cortagen is reported to stimulate cortical neuron growth and neurite outgrowth, support sciatic-nerve regeneration, and shift gene expression toward a neuroprotective, more youthful pattern — the basis for interest in cognition, memory, and nerve repair with aging. Unlike Semax or Selank, which work through neurotransmitters, it's proposed to act epigenetically by entering the nucleus and modifying chromatin. This is preclinical, Khavinson-group research, so it is not a proven treatment for any neurological condition.
Only the injectable research powder is reconstituted — the oral/sublingual form is taken as-is. For a 20 mg vial, adding 8 mL of bacteriostatic water gives 2.5 mg/mL, so a 500 mcg amount draws to 0.2 mL (20 units on a U-100 syringe); use less water to concentrate it. If you're stacking Cortagen with Vilon, Cardiogen, or Cartalax, reconstitute and measure each peptide in its own vial — the calculator works one compound at a time and shouldn't merge a blend.
Cortagen is not FDA- or EMA-approved and isn't a registered medicine — it's a research compound (with a supplement presence in Russia), and its entire evidence base comes from Khavinson's group with no independent Western replication or human trials. As a tiny tetrapeptide it's expected to be low-toxicity, but "no reported side effects" reflects limited study, not proof of safety, and real cognitive or nerve problems need proper neurological evaluation. Storage: keep the lyophilized powder frozen or cold and away from light, and refrigerate any reconstituted solution, using it within a few weeks.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.