N-Acetyl Selank Amidate Reconstitution Calculator

Structurally it's the same Selank core (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with two end-caps added — an acetyl group on the front (N-terminus) and an amide on the tail (C-terminus), written Ac-…-NH₂. Those caps block the aminopeptidase and carboxypeptidase enzymes that break plain Selank down fast, so the modified version is designed to resist degradation, last longer, and cross into the brain more readily. The target it acts on is unchanged, so for what it actually does — GABA modulation, serotonin/dopamine, BDNF, immune signaling — see the main Selank page; direct studies on the amidate itself are still thin, and it's assumed to behave like Selank.

They look alike but mean different things. The "N-acetyl" is a permanent structural cap built onto the peptide's N-terminus — part of the molecule itself — whereas "acetate" at the end of a product name is the salt form it's supplied as, an acetate counterion left over from purification and the gentler, more common alternative to a trifluoroacetate (TFA) salt. Practically, the acetate counterion plus a little bound water make up a small share of the labeled powder mass, so slightly less than the full listed weight is actual peptide — worth remembering if you want your post-reconstitution dose to be exact.

Only the lyophilized powder is reconstituted — trickle bacteriostatic water down the vial wall, swirl, and don't shake. As a worked example, a 10 mg vial with 6.25 mL of bacteriostatic water gives 1.6 mg/mL, so a 400 mcg research dose is 0.25 mL, which reads as 25 units on a U-100 insulin syringe. If the powder is an acetate salt, remember the true peptide content sits marginally below the labeled 10 mg, so treat that figure as a close approximation rather than an exact one.

The N-Acetyl Semax Amidate plus N-Acetyl Selank Amidate combo is sold as a stacked nasal product because the two do complementary jobs — focus from the Semax side, calm from the Selank side — but they're separate molecules and aren't interchangeable. There's no single validated "blend dose"; the sensible approach is to reason about each component on its own page rather than treat them as one drug. A pre-mixed nasal blend arrives ready to use, so nothing there gets reconstituted — this calculator is for a single injectable powder.

Plain Selank has a plasma half-life of only a couple of minutes, which is exactly the limitation the acetyl and amide caps were added to fix, so the amidate is expected to persist longer and may need dosing less frequently. That said, there's no validated, amidate-specific schedule, and researchers generally start from Selank reference dosing rather than anything purpose-built. Because the modification changes stability and possibly potency, don't assume a straight milligram-for-milligram swap with regular Selank.