Semax Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Work the dose out from body weight
Syringe size:
Possible vial strengths:
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Example Semax Titration Schedule
| Form | Dose | Frequency |
|---|---|---|
| Intranasal (studied) | 0.6–1.2 mg/day | 2–3× per day |
| Stroke (trial) | 6–18 mg/day IN | Course-based |
| SC (community) | 200–600 mcg | 1–2× per day |
All published human data are intranasal — FDA's advisory committee noted it could find no subcutaneous literature at all. The 500–1,500 mcg 'higher range' exceeds the community SC standard (200–600 mcg). Approved in Russia; PCAC review July 2026.
Possible vial strengths:
What Is It?
Semax
ACTH-derived peptide studied in cognition research.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Semax
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Semax Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
Semax is a synthetic seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) developed by the Russian Academy of Sciences from a fragment of ACTH, with a Pro-Gly-Pro tail added for stability. It's a nootropic and neuroprotective peptide — used to support focus, memory, and brain recovery — and importantly it was designed to keep the brain effects of ACTH while dropping the hormonal part, so it doesn't raise cortisol. It's most often used as a nasal spray, and also comes as a research powder.
The three are the same core peptide with escalating modifications. Plain Semax has the most clinical data but the shortest action; N-Acetyl Semax (NA-Semax) adds an acetyl group for roughly 2–3× the potency and longer duration; and N-Acetyl Semax Amidate (NASA) adds amidation too, making it the strongest and longest-acting (about 3–5×). That's why the modified versions are dosed at a fraction of standard Semax — matching them one-to-one would be an overdose.
Semax's main documented action is raising BDNF and NGF — growth factors tied to learning, memory, and neuron repair — while modulating dopamine and serotonin, which fits its reported effects on focus, mood, and mental stamina, especially under stress. It is not a classical stimulant and doesn't work like caffeine or amphetamine; effects are most noticeable when the brain is under load. Most evidence is Russian clinical and animal research with limited Western replication, and claims like hair-loss benefit are anecdotal, not established.
Semax is usually used as a pre-made nasal spray, which isn't reconstituted; only a research-grade powder is mixed. For a 10 mg vial, adding 2 mL of bacteriostatic water gives 5 mg/mL, so a 300 mcg amount draws to 0.06 mL (6 units on a U-100 syringe) — and note that N-Acetyl variants need a much smaller amount for the same effect. Because the plasma half-life is only minutes, the peptide clears fast even though its BDNF effect lasts far longer.
Semax is not FDA-approved in the US, though it's a registered prescription medicine in Russia and Ukraine; in the US it's available through 503A compounding pharmacies with a prescription (it was briefly on the FDA's Category 2 compounding list from 2023 until April 2026). Russian trials report a benign profile — mainly transient nasal irritation, mild headache, or a metallic taste — but there's no Western safety oversight or drug-interaction data, and the potent N-Acetyl variants warrant extra caution. Storage: keep the dry powder cold, and refrigerate reconstituted solution or nasal spray at around 4 °C, using it within a few weeks.
Practical takeaway: If your goal involves weight management, metabolic health, recovery, physical performance, cognitive function, appearance, or general well-being, discuss it with a licensed healthcare professional. They can help you evaluate approved, evidence-based options rather than relying on an unapproved or investigational compound. This calculator is intended only for transparent research-reference calculations and does not determine an appropriate amount, recommend use, or replace professional medical guidance.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.